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320 Furthermore, the induction of ZIP6 expression by STAT3 induces the translocation of ZIP6 to the plasma membrane and facilitates zinc influx, which is triggered by N-terminal cleavage

Severe constipation, painful bloating, vomiting, or inability to pass stool or gas

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Wetzels S, Wouters K, Schalkwijk CG, Vanmierlo T, Hendriks JJA

Nausea and Vomiting When it happens: Often worse when starting treatment and after increasing doses How to manage it: Eat smaller, more frequent meals