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A subsequent individual-level pooled data meta-analysis of these trials, which also accounted for the competing risks of mortality, demonstrated a significant 19% reduction in MI rates among patients with ischemic etiology of heart failure, 103 prompting a change in recommendations for these patients in the 2018 AHA/ACC/multispecialty guidelines

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ML algorithms are also able to screen genetic and molecular data to identify novel DPN biomarkers, accelerating targeted therapy development [54]