Efficacy and safety of lixisenatide once-daily versus placebo in patients with type 2 diabetes mellitus insufficiently controlled on sulfonylurea metformin (GetGoal-S.) [abstract 785]
Altered renal function has been reversed in many of the reported cases with supportive treatment and discontinuation of potentially causative agents, including liraglutide injection
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For most injectable GLP-1 receptor agonists (such as semaglutide injections, dulaglutide, and liraglutide), food has minimal impact on drug absorption because the medication is delivered directly into subcutaneous tissue and absorbed into the systemic circulation independently of the gastrointestinal tract
Likewise, the cardiovascular benefit of efpeglenatide was independent of GFR or the concomitant use of iSGLT-2, suggesting its additive and independent effect from the latter,85 as was also observed in the EXSCEL study.86 A recent meta-analysis of the 8 published cardiovascular safety clinical trials, and which included a total of 60