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Several segments in the ECD of GCGR, the stalk between ECD and transmembrane helix 1 (TM1) of GLP-1R (residues 130135), extracellular loop 1 (ECL1) of GIPR (residues 202207), and intracellular loop 3 (ICL3) of GLP-1R and GIPR (residues 338343 and 330333, respectively) were poorly resolved and not modeled in the structures

Toyota et al

2016;11(3): e0150042

2b), very low levels of semi-conservative (model 2) products were observed even after extended incubation in cells (3.1% after 30 min, Fig

However, their FDR values exceeded the acceptable threshold of 0.05, possibly due to the small sample sizes in some groups and the closely distributed acylcarnitine levels between cohorts, which may have influenced statistical power (Tong & Zhao, 2008)