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Recombinant human resistin causes insulin resistance via both the AMPK (AMP-activated protein kinase)-dependent and AMPK-independent suppressor of cytokine signalling-3 (SOCS-3) signalling pathways [25]
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A 2024 study on gene expression found that intermittent fasting significantly increased autophagy-related genes: LAMP2 expression rose approximately 4.2-fold, LC3B increased roughly 1.9-fold and ATG5 rose about 1.4-fold in participants with overweight or obesity
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As obesity management continues to evolve, therapies targeting multiple metabolic pathways may reshape how we approach treatmentnot only for weight reduction but potentially for broader cardiometabolic outcomes
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