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However, with the advent of NuSH therapies that offer pleiotropic effects, a multi-organ or systemic approach may prove more practical

Hydration plays a crucial role in metabolic function and peptide effectiveness

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Under hypoxic conditions, the stabilization of the HIF-1 protein occurs, leading to the translocation of the HIF-1 complex into the nucleus, which activates target genes crucial for cellular proliferation, survival, and differentiation (17, 62)