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In any period that a tax lot's cumulative loss exceeds 5%, the tax lot is sold, and the proceeds are immediately reinvested, plus any tax benefit, into a new tax lot

Mechanistically, systemic inflammation and circulating FFAs may target the hypothalamus, potentially inducing local microglial activation and reactive astrogliosis

Wagner et al., 2015

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What exists instead is mechanistic plausibility: tirzepatide drives fat loss at rates faster than most patients have experienced before, and glutathione is the endogenous compound responsible for managing oxidative debris at the cellular level