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Nevertheless, the alcoholic lungs in ethanol-fed animal models are under increased oxidative stress, have altered nitric oxide metabolism, express abnormal amounts of transforming growth factor TGF-, and are in a chronic proinflammatory state, with up-regulated expressions of IL-1 and tumor necrosis factor TNF-

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Sensitivity to hyperoxidation has so far been observed only in animal AhpC-PRX1 (i.e., typical 2-Cys PRXs), and causes its temporary inactivation until reactivated by the ATP-dependent enzyme Sulfiredoxin (SRX) (Fig