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2.2 Mitochondria metabolism In the quiescent state, neutrophils have low mitochondria density and weak mitochondrial activity, and the role of mitochondria in neutrophil function remains controversial (69)

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4.4 Modulation of itch signaling pathways Persistent or recurrent pruritus is a hallmark symptom of AD, and its pathogenesis is driven by complex interactions among upstream inflammatory mediators, neuronal sensitization mechanisms, and immune-driven processes (Tominaga and Takamori, 2022)