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I spent months doing computational modeling [to design peptides with amino acid structures that would engage with the receptors] within a narrow category as I couldnt choose a molecule that had previously been tested in a clinical context [because it could not then be legally marketed as a dietary supplement]

Efficacy and Safety of Mecobalamin on Peripheral Neuropathy PubMed / systematic review article: Concludes that mecobalamin (alone or combined) may improve clinical outcomes and nerve conduction in peripheral neuropathy

70 Gastric lavage, activated charcoal ingestion, and vomiting induced by ipececauanha can all reduce drug absorption, but weak evidence suggests activated charcoal as the preferred method of gastrointestinal decontamination