This is particularly beneficial for individuals living in urban areas, those exposed to chemicals, or anyone recovering from illness, medication use, or high levels of stress
When mast cells are activated in response to progesterone, the resulting histamine surge helps explain many of the hallmark features of APD, including: Hives (urticaria) caused by histamine-induced blood vessel dilation Intense itching (pruritus) driven by histamine signaling in the skin Angioedema , or deeper swelling beneath the skin and mucous membranes Asthma-like symptoms or shortness of breath , due to histamines effects on airway smooth muscle This mast cellhistamine connection also clarifies why treatments that target allergic pathways are often effective in APD, even though progesterone is a hormone rather than a classic allergen
Retrieved 2008-02-01
Circulation Palpitations, lightheadedness or variable blood pressure in susceptible patients
It plays a role in wound healing, tissue remodeling, and modulation of inflammation