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Despite the for research purposes only and not for human consumption labels, the FDA found evidence on the companies websites suggesting that their compounded products were intended as drugs for human use, making the labels misleading or false

Additional research is required to ascertain the variability in the risk of biliary diseases associated with GLP-1 RAs

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however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development

Biomolecules 9 (10), 517