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The European Medicines Agency (EMA) and MHRA continuously monitor the safety profile of all licensed medications through pharmacovigilance systems

Diabetic Retinopathy Considerations Patients with diabetic eye disease require close monitoring when starting Rybelsus

Cautions and Considerations Lack of regulation: Many natural supplements are not clinically tested for efficacy

To account for the continuing degeneration and atrophy in later stages, in the face of waning adaptive inflammation as the disease progresses, it has been proposed that the inflammation becomes trapped behind the bloodbrain barrier, continuing to damage the CNS, but now being inaccessible to peripherally-administered immunosuppressants

The impact on TMAO levels and whether this causally increases CVD risk is still uncertain