Calcitriol is the biologically active form of vitamin D that binds to the nuclear vitamin D receptor (nVDR)
Concomitant suppression of NLR family pyrin domain-containing 3 ( NLRP3 ), interleukin 6 ( IL6 ), and inhibin subunit Beta B ( INHBB ) specifically in M9a+sh EPAS1 versus M9a+shCTR indicated attenuated inflammation, while transcriptomic profiles showed no divergence between M9a+shCTR and M7/8+shCTR (Fig
Aging, stem cells and tissue regeneration: Lessons from muscle
This protective role is especially important in highly active tissues such as the liver, brain, heart, and muscles
Our previous study demonstrated that maternal HMSeBA (2-Hydroxy-4-methylselenobutanoic acid, a novel organic Se source) supplementation was beneficial for offsprings intestinal health by regulating inflammation and autophagy via MAPK/NF-B and ERK/Beclin-1 signaling pathways (16), while whether HMSeBA is involved in regulating ER stress signal of intestinal remains unclear
