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Tirzepatide is FDA-approved for treating type 2 diabetes mellitus (as Mounjaro) and chronic weight management in adults with obesity or overweight with weight-related comorbidities (as Zepbound), used alongside reduced-calorie diet and increased physical activity

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It is a short-term demonstration and will bridge into the Better Approaches to Lifestyle and Nutrition for Comprehensive hEalth Model, which aims to increase access to certain GLP-1 medications and healthy lifestyle interventions for those with Medicare and Medicaid

Avoid concomitant use of methylene blue with selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs) and opioids [see Warnings and Precautions (5.1) and Drug Interactions (7.1)]

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