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In clinical trials, severe gastrointestinal adverse reactions were reported more frequently among patients receiving Saxenda (4.8%) than placebo (1.4%)

Skin sagging is one of weight loss patients most signficant concerns

Constipation Some may find it hard to go to the toilet

In the UK, Ozempic is prescribed according to NICE guidelines for type 2 diabetes management (NG28), typically as part of dual or triple therapy when glycaemic targets are not met and where weight or cardiovascular considerations apply

Semaglutide also has evidence for cardiovascular risk reduction, while Wegovy was approved in 2025 for MASH with moderate-to-advanced liver fibrosis