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If a patient is still above the HbA1c target on an intensified insulin regimen, an option for treatment is switching one regimen with another (such as a basal-bolus regimen to premixed analog insulin three times daily or vice versa ) [3839]

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La estrategia de titulacin gradual est especficamente diseada para minimizar estos efectos

Among the array of chemotherapeutics, methotrexate and 6-mercaptopurine are used during the maintenance phase of ALL treatment, both of which are implicated in hepatotoxicity