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The mechanism involved T4 activating integrin-linked kinase (ILK) and Akt activity, promoting cardiac cell migration and survival, and stimulating stem cell activation and differentiation

They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology

But the data has gaps and limits

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