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Gene set enrichment analysis (GSEA) was performed with 1000 permutations to identify enriched biological functions and activated pathways from the molecular signatures database (MSigDB), which included hallmark gene sets, positional gene sets, curated gene sets, motif gene sets, computational gene sets, GO gene sets, oncogenic gene sets, and immunologic gene sets

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The standard titration exists because decades of clinical research determined that this pace minimizes adverse events while maximizing long-term adherence

Surgical Approaches in Esophageal Cancer