In a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity by modulating enteric neuronal function through GLP-1 receptors in submucosal and myenteric ganglion neurons [52]
Observational research presented in March 2026 at the American Academy of Orthopaedic Surgeons annual meeting found that GLP-1 drugs may slightly increase the risk of developing osteoporosis and gout, a kind of inflammatory arthritis caused by a buildup of uric acid
Additionally, it slows gastric emptying, prolonging the feeling of fullness and aiding in weight loss
Nasal strips, which physically open the nasal passages, can help redirect breathing through the nose
95% CI, 0.53-0.69), though there was no statistically significant difference between the groups in the risk of MACE (HR, 1.10