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AT-7687, a novel GIPR peptide antagonist, combined with a GLP-1 agonist, leads to enhanced weight loss and metabolic improvements in cynomolgus monkeys

Studies 1 (RCT) and 2 (cross-ectional) are underway (commenced Oct 2022), all remaining studies studies are planned to be completed by summer 2026

Importantly, these immune alterations frequently coexist with decidualization and stromal niche defects identified by single-cell transcriptomic analyses, suggesting that risk arises from interacting biological programs rather than isolated abnormalities [378]

This peptide works by stimulating the breakdown of stored fat and inhibiting the formation of new fat cells, a process known as lipolysis

BP isoflavones have been used as anticancer agent against breast cancer cells such as triple-negative breast cancer (TNBC) and restrain the activity of endogenous estrogen (177)