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The acquired micrographs were inverted using the EMAN2 37 to facilitate particle picking in cryoSPARC 38

Work areas should be equipped with standard laboratory safety infrastructure, including proper ventilation, waste disposal systems, and spill response protocols

Cystine enters cells through system Xc- and is reduced to cysteine via the thioredoxin reductase 1 (TXNRD1)-dependent pathway and then contributes to GSH production (Fig

Furthermore, expression of SLC7A11, a GSTO1 and C1-27 target gene, was increased in C1-27 -treated tumours indicating target engagement (Fig