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That said, it is important to note that the ability of topical L-carnitine to reduce cellulite still requires further study

Changes in their levels may serve as potential biomarkers for the early diagnosis and prognosis of this disease

This discrepancy primarily stems from methodological variations in patient selection, intervention design, and endpoint assessment, rather than contradicting the established biological plausibility of LC's mechanisms

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Biological fluid samples are readily available, and effective small changes in gene and protein expression are amplified on metabolites, thus making mass spectrometry detection easier and more sensitive, and reflecting the real pathophysiological state of organisms more directly and accurately (Zhou et al