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Excess adipose tissue, particularly visceral fat, promotes systemic inflammation and insulin resistance while reducing testosterone levels through increased aromatase activity that converts testosterone to estrogen

Quantitative PCR analysis of peripheral blood samples revealed that GADD45A expression levels were significantly decreased in ASD patients in both cohorts (Fig

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Moreover, recent studies have shown a strong relationship between bone metabolism and intestinal microbiota, and their potential effect on the risk of developing osteoporosis [10]