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American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology, 283, R99R106

The induction of the NADPH oxidase (NOX) system by proinflammatory mediators can generate BBB permeability by downregulation of proteins involved in intercellular junctions such as VE-cadherin, occludin, and claudin-5 (Rochfort et al., 2014)

Most cases of MS are benign though 10% of them are malignant with metastasis that is characterized by epithelioid cells with variably sized nuclei and marked accumulation of melanin in neoplastic cells and melanophages [2, 5]

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During the 17th century, Nicholas Culpeper, a pharmacist, used the derivatives of milk thistle in treating the obstructions of liver and spleen