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Most protocols follow a two-phase structure: a loading phase of one to three sessions per week for several weeks, then maintenance visits every one to two weeks

The day before the experiment, 2,000 cells/well were seeded in 96-well plates (Corning)

Angioni D, Middleton L, Bateman R et al (2025) Challenges and opportunities for novel combination therapies in Alzheimers disease: a report from the EU/US CTAD Task Force

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Acetylcarnitine, on the other hand, affects the epigenetic regulation of metabotropic glutamate type 2 receptors (mGluR2), negatively modulating neurotransmitter release and producing rapid and long-lasting antidepressant effects (demonstrated by forced swim tests, sucrose preference tests) in Flinders Sensitive Line rats and in mice exposed to chronic unpredictable stress, which model genetic and environmentally induced depression, respectively [92]