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Paroxetine is the only antidepressant approved for use in treating postmenopausal hot flashes, but escitalopram has demonstrated similar benefits

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Short- to medium-term trial data show neutral-to-favorable effects on key cardiometabolic risk markers, but definitive evidence on major adverse cardiovascular events (MACE) requires dedicated, long-term outcome trials

Patience during the titration phase pays dividends in long-term tolerability

These changes usually appear within 2 to 3 months