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doi: 10.1101/gad.991402 138 Le GallL.AnakorE.ConnollyO.VijayakumarU.DuddyW.DuguezS

Structural modifications, such as fatty acid conjugation, may allow the peptide to remain active longer in experimental environments, providing researchers with extended observation periods

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Once your body adjusts to the smaller melatonin dosage, you can increase your dosage as needed