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doi: 10.1016/j.cmet.2017.01.009 68 Camunas-SolerJDaiXQHangYBautistaALyonJSuzukiKet al

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In patients with Neurofibromatosis type 1 (NF1), malignant transformation of a pre-existing plexiform neurofibroma may be indicated by a sudden increase in size, new-onset pain, or neurologic deficits

label similarly describes postmarketing acute kidney injury events often occurring in patients who experienced gastrointestinal reactions leading to dehydration, and recommends monitoring renal function in those with reactions that could lead to volume depletion