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out of these, five patients had preload failure and met the criteria for myalgic encephalitis/chronic fatigue syndrome ( Phillip Decreased peak Vo2 and low cardiac output were reported in low-flow patients with decreased biventricular filling pressure secondary to low venous pressure that was not explained by intrinsic heart disease or pulmonary hypertension ( The second group with low peak Vo2 had a high cardiac output and was found to have an impairment of systemic oxygen extraction

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