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Life Sci 2006;78: 80311

7 Summary and outlook Disruption of gut microbial homeostasis is a major driver of UC onset and progression

No Observed Effects On: Blood glucose or insulin sensitivity (no diabetogenic effects) IGF-1 levels (remained within normal ranges) Blood pressure or cardiovascular parameters Thyroid function Liver or kidney function markers Important: The absence of growth hormone-related side effects distinguishes AOD-9604 from full-length GH, which can cause fluid retention, joint pain, carpal tunnel syndrome, and insulin resistance

Despite its higher cost, its novel mechanism of action and superior clinical efficacy set it apart from many traditional weight loss options

Kaiser 1999