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What to Tell Your Anesthesiologist About GLP-1 Therapy Before your surgery, your anesthesiologist needs to know the name of your GLP-1 medication (semaglutide or tirzepatide), your current dose, how long you've been taking it, the date of your last injection or dose, and whether you're pausing as planned before the operation

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Even when injected systemically in the abdominal area, the peptide concentrates at injury sites throughout the body

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Due to the increased amount of adipose tissue, obese patients are more predisposed to systemic inflammation with higher levels of pro-inflammatory cytokines, such as interleukin 6, eotaxin-1, TNF-, transforming growth factor beta 1 (TGF-1) and CRP