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IGF-1 LR3 is a modified IGF-1 with an extended amino acid sequence that has 13 additional amino acids at the N-terminus and a substitution of arginine for glutamic acid at position 3

Because B12 symptoms can look like symptoms of other diseases, diagnosing a B12 deficiency can be challenging

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The dose-adjusted within-participant accumulation ratio (R ac ) was calculated using participant matched day 1 and 7 data and day 1 and 14 data, as follows: (AUC 0- , Day 7 /Day 7 Dose)/(AUC 0- , Day 1 /Day 1 Dose) and (AUC 0- , Day 14 /Day 14 Dose)/(AUC 0- , Day 1 /Day 1 Dose)