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Fluorescence lifetime images of 512 x 512 pixels (135.2 m x 135.2 m) and 2 cycles or 5 x 10 5 photon counts at a pixel dwell time of 16.38 s passing through a 550 49 nm bandpass filter (Semrock, F37-551, IDEX Health & Science, LLC, Rochester, NY, United States) were recorded using the handshake plugin between Zen Black imaging software (Carl Zeiss AG, Oberkochen, Germany) and SymPhoTime 64 software (PicoQuant, Berlin, Germany)