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Targeting the incretin/glucagon system with multi-receptor agonists Furthermore, novel GLP-1/GCG hybrid peptides with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide (GIP), and GLP-1/GCG receptors have been developed which amplify the well-established physiological incretin effect and appear to have powerful insulin-releasing, glucoregulatory properties and pancreatic beta-cell protective actions [40]

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Due to insufficient retrieved dropout data (that is, data from participants who discontinued treatment but remained in the study), a control-based imputation approach using the placebo group was selected as a more conservative strategy