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Any factor that affects this intraocular environment, such as aging, genetics, metabolic abnormalities, trauma, radiation, poisoning, local nutritional disorders, and certain systemic metabolic or immune diseases, can directly or indirectly cause the lens to become opaque

PMID: 31309300

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Clinical studies have begun to reveal the relevance of this pathway, with LINC01133 expression showing significant downregulation in bronchial epithelial cells from patients with severe asthma, correlating with increased lipid peroxidation markers