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Most of these were mild to moderate and occurred mainly during dose escalation

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Moreover, especially among the upregulated genes, the majority of the gene expression changes in the fem-3(-) mutants were found within the set of changes identified in the glp-1(-) mutant

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In regard to eNOS function, 5-methyltetrahydrofolate (MTHF), the active form of folic acid, does not have an effect on pterin-free eNOS, but directly interferes with BH 4 -repleted, partially uncoupled eNOS, shifting it from superoxide production toward NO production (Stroes et al., 2000)