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These shortcomings give rise to a lower mitochondrial membrane potential, heightened ROS generation, and the initiation of apoptotic pathways like caspase-3 (47)

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Growing evidence from observational studies indicates that treatment of obesity with bariatric surgery improves cardiovascular outcomes, but these findings have not been confirmed in randomized trials, largely because of randomization challenges with bariatric surgery

All of these studies are hypothesis-generating and await confirmation in RCTs. According to Lane, the rationale for GLP-1 receptor agonists in lupus stems from the drugs demonstrating anti-inflammatory properties, potentially by inhibiting the NF-B pathway, which plays a crucial role in inflammation