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SCFAs are synthesized from indigestible carbohydrates by bacteria such as Firmicutes , Bacteroidetes , and Bifidobacteria [145], as well as Akkermansia, Lactobacillus [142, 146], and Prevotella [147]

Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

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To quantify the frequency of interaction between GSSG functional groups and protein residues, the pairwise distances between all GSSG functional group atoms and protein atoms were calculated for each trajectory frame

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