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The role of barrier-respecting correction Effective cosmetic correction of a labial melanotic macule requires the same principles as the correction of broader lip hyperpigmentation: gentle exfoliation that respects the barrier, melanin synthesis inhibition at the enzymatic source, and barrier restoration to break the inflammatory cycle

It further validates our model of delivering high-value, IP-led assets in challenging therapeutic segments

The between-group difference in TCSS improvement was statistically significant ( P 0.1)

The critical organelle affected is the mitochondria, whose disruption induces reduction in ATP generation and apoptosis or necrosis [51]