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Vamifeport (VIT-2763), as a novel oral FPN inhibitor, induces dose-dependent internalization and ubiquitination of FPN in cells, improving iron homeostasis in mouse models of -thalassemia
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IGF-mediated proliferation process of theca cell has been verified in ex vivo model of sheep, to the extent that high IGF levels led to theca cell overgrowth [12]
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