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Akt activation also attenuates apoptosis indirectly by antagonizing forkhead box subfamily O transcription factor 3a pathways to promote the expression of the caspase 8 inhibitor, FLICE-inhibitory protein (181, 333)

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Acknowledgments During the preparation of this work, the authors used ChatGPT 4o by Open AI to improve paper readability

229,230 Conclusion In summary, GLP-1RAs and dual-receptor agonists targeting both GLP-1 and GIP receptors have introduced significant advancements in the management of endocrine and metabolic disorders and their associated complications, establishing themselves as central therapeutic modalities within this domain