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In terms of renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria and not on hard kidney endpoints [3, 6, 8]

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This aligns with Kyoto Encyclopedia of Genes and Genomes enrichment linked GSH metabolism to ferroptosis and TNF signaling ( 4.4 Future therapeutic targets The Nrf2/HO-1/GPX4 axis and GSH pathways are promising therapeutic targets for SAE

A maternal High-Fat diet induces DNA methylation changes that contribute to glucose intolerance in offspring