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However, based on current research data, metabolic factors cannot be ruled out as potential contributing factors

A total of 1201 patients were randomly assigned to treatment between Jan 6, 2016, and June 22, 2016

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Bipolar disorder: A landmark RCT (n=75) found that NAC (1,000 mg twice daily for 24 weeks) produced a significant improvement in depression scores (Montgomery-Asberg Depression Rating Scale) in bipolar disorder as an adjunct to usual treatment (Berk et al., Biol Psychiatry, 2008) [74]

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