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However, the results emphasize how important prospective and randomized studies would be to more precisely examine the potential effects of the drugs and clearly distinguish between drug effects, weight loss, and general health differences.

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This remains a hypothesis built to explain a database observation, not a mapped and validated pathway, and the distance between a compound shifts a gene signature in cultured cells and a systemically dosed animal, let alone a person, experiences a coordinated health benefit is exactly the distance that has not been closed

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