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In MetS, events such as increased oxidative stress and inflammatory cytokines generated by hyperglycemia and obesity can cause vascular endothelial dysfunction, compromising the vasomotor balance and increasing the adhesion of leukocytes to the endothelium in various organs and tissues, including the central nervous system (CNS) [7,8,9]

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Im not sure why this wasnt part of the first intake, but its quick

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