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One of the ways it does this is by slowing emptying of the stomach so there is a feeling of satiety. Ibiye Owei, MD, assistant professor at Texas Tech University Health Sciences Center Related articles: Sources:

A powerful, science-backed combination is quietly reshaping metabolism, energy, and weight regulation

Side effects may also occur because appetite changes quickly

When dose escalation to 12.5mg or 15mg is appropriate If you have been at 10mg for 12 or more weeks, have optimized nutrition and activity, and have confirmed a genuine plateau (no weight change for 8 or more consecutive weeks despite adherence), then escalation to 12.5mg may be warranted

This biological rebound typically occurs 612 months into treatment and creates the illusion that semaglutide has stopped working