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The repeated finding that E-domain effects are strongest in young, growing tissue and blunted with age seen both in cultured human satellite cells [6] and in virally treated mouse muscle [21] is a particularly pointed reminder that the models most likely to show a positive result are the least representative of the adult humans who feature in performance narratives

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Decades of research have expanded our understanding of its complex pathogenesis, yet current treatments offer only temporary symptomatic relief without significantly altering disease progression