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Who Should Avoid It Personal or family history of medullary thyroid cancer Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy or breastfeeding History of pancreatitis Stop Right Away If You Notice Severe persistent abdominal pain (possible pancreatitis) Persistent vomiting preventing fluid intake Signs of thyroid tumor (neck lump, hoarseness, trouble swallowing) Severe allergic reaction (rash, itching, difficulty breathing) Vision changes (possible diabetic retinopathy progression) Severe hypoglycemia (if combined with insulin/sulfonylureas) Kidney problems (decreased urination, swelling) Milder Signs to Watch For How Long Should a GLP-1 (Semaglutide) Cycle Last

Pregnancy test PRN (serum/urine human chorionic gonadotropin level)

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