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The Diagnostic and Statistical Manual of Mental Disorders IV-Text Revised (DSM-IV-TR) described autism as a complex neurobehavioral disorder characterized by varying degrees of social interaction deficits, flexibility of thinking, specific language abnormalities and/or delayed cognition, impaired verbal and non-verbal communication, failure to respond to certain stimuli with some restricted and extreme repetitive behavior or actions, stereotyped patterns of behavior or circumscribed interests, and association with several metabolic disorders

Step-therapy mandates that patients fail metformin or orlistat add 36 months to initiation timelines, increasing dropout risk

doi: 10.1056/NEJMp1500523 73 AcostaACamilleriMAbu DayyehBCalderonGGonzalezDMcRaeAet al

The biggest safety concern is heart health

The USD 16.5 billion deal, closed at the end of 2024, will transfer three key Catalent factories to Novo Nordisk for about USD 11.5 billion